IL1RL1

GENERAL INFORMATION

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Gene name

IL1RL1

Gene description

Interleukin 1 receptor-like 1

Protein class

Candidate cardiovascular disease genes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Intracellular,Membrane,Secreted

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (placenta)
GTEx:Tissue enhanced (kidney, lung)

Protein evidence

Evidence at protein level

Protein localization

RNA data suggests high expression in placenta. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 2 antibodies.
HPA007406 , HPA007917
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (placenta)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (kidney, lung)

Organ

Expression



GENE INFORMATION

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Gene name

IL1RL1 (HGNC Symbol)

Synonyms

DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1

Description

Interleukin 1 receptor-like 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q12.1

Chromosome location (bp)

102311502 - 102352037

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000115602 (version 78.38)

Entrez gene

9173

UniProt

Q01638 (UniProt - Evidence at protein level)

neXtProt

NX_Q01638

Antibodypedia

IL1RL1 antibodies


PROTEIN BROWSER

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ENST00000233954
 
ENST00000311734
 
ENST00000404917
 
ENST00000409584
 
ENST00000447231
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL1RL1-001 ENSP00000233954
ENST00000233954
Q01638
Show all »
Show » Show » 556 63.4 Yes 1
IL1RL1-002 ENSP00000310371
ENST00000311734
Q01638
Show all »
Show » Show » 328 37 Yes 0
IL1RL1-004 ENSP00000409437
ENST00000447231
C9JSY6
Show all »
Show » 38 4.4 Yes 0
IL1RL1-008 ENSP00000386618
ENST00000409584
E9PC41
Show all »
Show » Show » 314 35.6 Yes 0
IL1RL1-201 ENSP00000384822
ENST00000404917
Q01638
Show all »
Show » Show » 211 23.7 No 0