RPL22

GENERAL INFORMATION

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Gene name

RPL22

Gene description

Ribosomal protein L22

Protein class

Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Ribosomal proteins

Predicted localization

Intracellular

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY

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Data reliability

Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A


PROTEIN EXPRESSION OVERVIEW

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Pending normal tissue annotation.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

RPL22 (HGNC Symbol)

Synonyms

EAP, L22

Description

Ribosomal protein L22 (HGNC Symbol)

Entrez gene summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p36.31

Chromosome location (bp)

6181269 - 6209389

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000116251 (version 78.38)

Entrez gene

6146

UniProt

P35268 (UniProt - Evidence at protein level)

neXtProt

NX_P35268

Antibodypedia

RPL22 antibodies


PROTEIN BROWSER

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ENST00000234875
 
ENST00000462296
 
ENST00000465335
 
ENST00000465387
 
ENST00000471204
 
ENST00000484532
 
ENST00000497965
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RPL22-001 ENSP00000346088
ENST00000234875
P35268
Show all »
Show » Show » 128 14.8 No 0
RPL22-002 ENSP00000468274
ENST00000497965
K7ERI7
Show all »
Show » Show » 95 11.2 No 0
RPL22-004 ENSP00000465763
ENST00000484532
K7EKS7
Show all »
Show » Show » 53 5.7 No 0
RPL22-005 ENSP00000466013
ENST00000465387
K7ELC4
Show all »
Show » Show » 79 9.1 No 0
RPL22-006 ENSP00000465313
ENST00000465335
K7EJT5
Show all »
Show » Show » 47 5.1 No 0
RPL22-007 ENSP00000466502
ENST00000471204
K7EMH1
Show all »
Show » Show » 89 10.4 No 0
RPL22-008 ENSP00000467247
ENST00000462296
K7EP65
Show all »
Show » Show » 48 5.2 No 0