KCNJ8

GENERAL INFORMATION

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Gene name

KCNJ8

Gene description

Potassium inwardly-rectifying channel, subfamily J, member 8

Protein class

Disease related genes
FDA approved drug targets
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

Membrane

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Squamous epithelia, stomach, small intestine, liver, pancreatic ductal cells, thyroid, adrenal cortex, renal tubuli, urothelia and megakaryocytes displayed moderate to strong cytoplasmic positivity. Remaining normal tissues were either negative or weakly stained.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA031066
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

KCNJ8 (HGNC Symbol)

Synonyms

Kir6.1

Description

Potassium inwardly-rectifying channel, subfamily J, member 8 (HGNC Symbol)

Entrez gene summary

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS). [provided by RefSeq, May 2012]

Chromosome

12

Cytoband

p12.1

Chromosome location (bp)

21764955 - 21775581

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000121361 (version 78.38)

Entrez gene

3764

UniProt

Q15842 (UniProt - Evidence at protein level)

neXtProt

NX_Q15842

Antibodypedia

KCNJ8 antibodies


PROTEIN BROWSER

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ENST00000240662
 
ENST00000537950
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KCNJ8-001 ENSP00000240662
ENST00000240662
Q15842
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Show » Show » 424 48 No 2
KCNJ8-002 ENSP00000440012
ENST00000537950
F5GY12
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Show » Show » 114 13.3 No 1