AKT1

GENERAL INFORMATION

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Gene name

AKT1

Gene description

V-akt murine thymoma viral oncogene homolog 1

Protein class

Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

Intracellular

Number of transcripts

11
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous nuclear expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data.

Data reliability

Supportive based on 2 antibodies.
HPA002891 , CAB003765
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

AKT1 (HGNC Symbol)

Synonyms

AKT, PKB, PRKBA, RAC

Description

V-akt murine thymoma viral oncogene homolog 1 (HGNC Symbol)

Entrez gene summary

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]

Chromosome

14

Cytoband

q32.33

Chromosome location (bp)

104769349 - 104795751

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000142208 (version 78.38)

Entrez gene

207

UniProt

P31749 (UniProt - Evidence at protein level)

neXtProt

NX_P31749

Antibodypedia

AKT1 antibodies


PROTEIN BROWSER

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ENST00000349310
 
ENST00000402615
 
ENST00000407796
 
ENST00000544168
 
ENST00000554192
 
ENST00000554581
 
ENST00000554848
 
ENST00000555380
 
ENST00000555458
 
ENST00000555528
 
ENST00000555926
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AKT1-001 ENSP00000270202
ENST00000349310
P31749
Show all »
Show » Show » 480 55.7 No 0
AKT1-002 ENSP00000384293
ENST00000407796
P31749
Show all »
Show » Show » 480 55.7 No 0
AKT1-003 ENSP00000385326
ENST00000402615
P31749
Show all »
Show » Show » 480 55.7 No 0
AKT1-004 ENSP00000451166
ENST00000554848
P31749
Show all »
Show » Show » 480 55.7 No 0
AKT1-005 ENSP00000451828
ENST00000554581
P31749
Show all »
Show » Show » 480 55.7 No 0
AKT1-006 ENSP00000450688
ENST00000555528
P31749
Show all »
Show » Show » 480 55.7 No 0
AKT1-007 ENSP00000443897
ENST00000544168
P31749
Show all »
Show » Show » 418 48.3 No 0
AKT1-010 ENSP00000450681
ENST00000554192
G3V2I6
Show all »
Show » Show » 184 20.9 No 0
AKT1-013 ENSP00000451290
ENST00000555380
G3V3K5
Show all »
Show » Show » 105 12.2 No 0
AKT1-014 ENSP00000451824
ENST00000555926
G3V4I6
Show all »
Show » 92 11 No 0
AKT1-018 ENSP00000451470
ENST00000555458
G3V3X1
Show all »
Show » Show » 170 19.3 No 0