PIK3CA

GENERAL INFORMATION

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Gene name

PIK3CA

Gene description

Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

Protein class

Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression, often with a granular pattern.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA009985 , CAB017804
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PIK3CA (HGNC Symbol)

Synonyms

PI3K

Description

Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (HGNC Symbol)

Entrez gene summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

q26.32

Chromosome location (bp)

179148114 - 179240093

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000121879 (version 78.38)

Entrez gene

5290

UniProt

P42336 (UniProt - Evidence at protein level)

neXtProt

NX_P42336

Antibodypedia

PIK3CA antibodies


PROTEIN BROWSER

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ENST00000263967
 
ENST00000468036
 
ENST00000477735
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PIK3CA-001 ENSP00000263967
ENST00000263967
P42336
Show all »
Show » Show » 1068 124.3 No 0
PIK3CA-002 ENSP00000418145
ENST00000477735
C9J951
Show all »
Show » 21 2.4 No 0
PIK3CA-003 ENSP00000417479
ENST00000468036
C9JAM9
Show all »
Show » Show » 118 13.8 No 0