DDX3X

GENERAL INFORMATION

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Gene name

DDX3X

Gene description

DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked

Protein class

Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in several tissues. High expression observed in exocrine pancreas and lymphoid germinal center cells.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 2 antibodies.
HPA001648 , HPA005631
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

DDX3X (HGNC Symbol)

Synonyms

DBX, DDX14, DDX3, HLP2

Description

DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Chromosome

X

Cytoband

p11.4

Chromosome location (bp)

41333348 - 41364472

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000215301 (version 78.38)

Entrez gene

1654

UniProt

O00571 (UniProt - Evidence at protein level)

neXtProt

NX_O00571

Antibodypedia

DDX3X antibodies


PROTEIN BROWSER

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ENST00000399959
 
ENST00000441189
 
ENST00000457138
 
ENST00000611968
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DDX3X-001 ENSP00000382840
ENST00000399959
O00571
Show all »
Show » Show » 662 73.2 No 0
DDX3X-005 ENSP00000414281
ENST00000441189
B4DLA0
Show all »
Show » Show » 139 15 No 0
DDX3X-012 ENSP00000479790
ENST00000611968
Show » 138 14.7 No 0
DDX3X-201 ENSP00000392494
ENST00000457138
O00571
Show all »
Show » Show » 646 71.4 No 0