ATP6V1F

GENERAL INFORMATION

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Gene name

ATP6V1F

Gene description

ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F

Protein class

Predicted intracellular proteins
Transporters

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic and membranous expression in several tissues including kidney tubules and islets of Langerhans.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA048700 , HPA062011 , CAB009529
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

ATP6V1F (HGNC Symbol)

Synonyms

ATP6S14, VATF, Vma7

Description

ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F (HGNC Symbol)

Entrez gene summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c"", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is the V1 domain F subunit protein. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

q32.1

Chromosome location (bp)

128862826 - 128865844

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000128524 (version 78.38)

Entrez gene

9296

UniProt

Q16864 (UniProt - Evidence at protein level)

neXtProt

NX_Q16864

Antibodypedia

ATP6V1F antibodies


PROTEIN BROWSER

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ENST00000249289
 
ENST00000492758
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP6V1F-001 ENSP00000249289
ENST00000249289
Q16864
Show all »
Show » Show » 119 13.4 No 0
ATP6V1F-002 ENSP00000417378
ENST00000492758
Q16864
Show all »
Show » Show » 147 16.4 No 0