IL12A

GENERAL INFORMATION

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Gene name

IL12A

Gene description

Interleukin 12A

Protein class

Cancer-related genes
Plasma proteins
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (esophagus)
GTEx:Tissue enhanced (esophagus)

Protein evidence

Evidence at protein level

Protein localization

Most normal cells showed weak to moderate cytoplasmic positivity. Exocrine pancreas, deeper glands in gastric mucosa and trophoblastic cells in placenta displayed strong immunoreactivity.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA001886
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (esophagus)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (esophagus)

Organ

Expression



GENE INFORMATION

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Gene name

IL12A (HGNC Symbol)

Synonyms

CLMF, IL-12A, NFSK, NKSF1, p35

Description

Interleukin 12A (HGNC Symbol)

Entrez gene summary

This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

q25.33

Chromosome location (bp)

159988750 - 159996019

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000168811 (version 78.38)

Entrez gene

3592

UniProt

P29459 (UniProt - Evidence at protein level)

neXtProt

NX_P29459

Antibodypedia

IL12A antibodies


PROTEIN BROWSER

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ENST00000305579
 
ENST00000466512
 
ENST00000480787
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL12A-001 ENSP00000303231
ENST00000305579
P29459
Show all »
Show » Show » 253 28.3 No 1
IL12A-005 ENSP00000420184
ENST00000480787
E7ENE1
Show all »
Show » Show » 215 24 No 1
IL12A-006 ENSP00000419046
ENST00000466512
E9PGR3
Show all »
Show » Show » 239 26.7 No 1