DLG4

GENERAL INFORMATION

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Gene name

DLG4

Gene description

Discs, large homolog 4 (Drosophila)

Protein class

Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (cerebellum, cerebral cortex, hippocampus)

Protein evidence

Evidence at protein level

Protein localization

Distinct cytoplasmic expression in CNS, including cerebellar basket cells.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data. Presumed off target binding observed and disregarded.

Data reliability

Supportive based on 3 antibodies.
HPA010122 , CAB001999 , CAB002000
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (cerebral cortex)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (cerebellum, cerebral cortex, hippocampus)

Organ

Expression



GENE INFORMATION

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Gene name

DLG4 (HGNC Symbol)

Synonyms

PSD-95, PSD95, SAP-90, SAP90

Description

Discs, large homolog 4 (Drosophila) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

p13.1

Chromosome location (bp)

7189890 - 7219702

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000132535 (version 78.38)

Entrez gene

1742

UniProt

P78352 (UniProt - Evidence at protein level)

neXtProt

NX_P78352

Antibodypedia

DLG4 antibodies


PROTEIN BROWSER

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ENST00000302955
 
ENST00000399506
 
ENST00000399510
 
ENST00000447163
 
ENST00000451807
 
ENST00000485100
 
ENST00000486626
 
ENST00000493294
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DLG4-001 ENSP00000382428
ENST00000399510
P78352
Show all »
Show » Show » 767 85.4 Yes 0
DLG4-002 ENSP00000382425
ENST00000399506
P78352
Show all »
Show » Show » 724 80.5 No 0
DLG4-003 ENSP00000307471
ENST00000302955
P78352
Show all »
Show » Show » 721 80.1 No 0
DLG4-004 ENSP00000460625
ENST00000485100
O14909
Show all »
Show » Show » 296 31.9 No 0
DLG4-006 ENSP00000407918
ENST00000451807
C9JYG3
Show all »
Show » Show » 281 30.1 No 0
DLG4-007 ENSP00000388122
ENST00000447163
C9JWP9
Show all »
Show » Show » 234 25 No 0
DLG4-008 ENSP00000465789
ENST00000493294
K7EKU8
Show all »
Show » Show » 91 9.8 No 0
DLG4-009 ENSP00000465720
ENST00000486626
K7EKP9
Show all »
Show » Show » 116 12.4 No 0