CD180

GENERAL INFORMATION

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Gene name

CD180

Gene description

CD180 molecule

Protein class

CD markers
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (lymph node, tonsil)
GTEx:Group enriched (small intestine, spleen)

Protein evidence

Evidence at protein level

Protein localization

Selective cytoplasmic expression in a subset of immune cells.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
HPA003740
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (lymph node, tonsil)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (small intestine, spleen)

Organ

Expression



GENE INFORMATION

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Gene name

CD180 (HGNC Symbol)

Synonyms

LY64, Ly78, RP105

Description

CD180 molecule (HGNC Symbol)

Entrez gene summary

CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q12.3

Chromosome location (bp)

67182275 - 67196799

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000134061 (version 78.38)

Entrez gene

4064

UniProt

Q99467 (UniProt - Evidence at protein level)

neXtProt

NX_Q99467

Antibodypedia

CD180 antibodies


PROTEIN BROWSER

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ENST00000256447
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD180-001 ENSP00000256447
ENST00000256447
Q99467
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Show » Show » 661 74.2 Yes 1