HLA-DQA1

GENERAL INFORMATION

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Gene name

HLA-DQA1

Gene description

Major histocompatibility complex, class II, DQ alpha 1

Protein class

Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Tissue enhanced (lung, spleen)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression mainly in lymphoid tissue, alveolar macrophages, Langerhans cells in skin and immune cells in several different tissue types.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Data reliability

Supportive based on 1 antibody.
HPA012315
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (lung, spleen)

Organ

Expression



GENE INFORMATION

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Gene name

HLA-DQA1 (HGNC Symbol)

Synonyms

CELIAC1, HLA-DQA

Description

Major histocompatibility complex, class II, DQ alpha 1 (HGNC Symbol)

Entrez gene summary

HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p21.32

Chromosome location (bp)

32628179 - 32647062

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000196735 (version 78.38)

Entrez gene

3117

UniProt

P01909 (UniProt - Evidence at protein level)

neXtProt

NX_P01909

Antibodypedia

HLA-DQA1 antibodies


PROTEIN BROWSER

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ENST00000343139
 
ENST00000374949
 
ENST00000395363
 
ENST00000422863
 
ENST00000496318
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HLA-DQA1-001 ENSP00000339398
ENST00000343139
P01909
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Show » Show » 255 28 Yes 1
HLA-DQA1-004 ENSP00000378767
ENST00000395363
P01909
Show all »
Show » Show » 255 28 Yes 1
HLA-DQA1-007 ENSP00000437302
ENST00000496318
E9PMV2
Show all »
Show » Show » 214 23.7 Yes 0
HLA-DQA1-009 ENSP00000364087
ENST00000374949
P01909
Show all »
Show » Show » 255 28 Yes 1
HLA-DQA1-010 ENSP00000405797
ENST00000422863
F6UB03
Show all »
Show » 24 2.4 Yes 0