TRPM1

GENERAL INFORMATION

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Gene name

TRPM1

Gene description

Transient receptor potential cation channel, subfamily M, member 1

Protein class

Disease related genes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

Intracellular,Membrane

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (skin, testis)
GTEx:Group enriched (skin, testis)

Protein evidence

Evidence at protein level

Protein localization

RNA-based expert annotation could not be performed.

ANTIBODY RELIABILITY

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Data reliability
description

Presumed off target binding observed and disregarded. Pending external verification.

Data reliability

Uncertain based on 1 antibody.
HPA014785
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (skin, testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (skin, testis)

Organ

Expression



GENE INFORMATION

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Gene name

TRPM1 (HGNC Symbol)

Synonyms

CSNB1C, LTRPC1, MLSN1

Description

Transient receptor potential cation channel, subfamily M, member 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

Chromosome

15

Cytoband

q13.3

Chromosome location (bp)

31001061 - 31161273

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000134160 (version 78.38)

Entrez gene

4308

UniProt

Q7Z4N2 (UniProt - Evidence at protein level)

neXtProt

NX_Q7Z4N2

Antibodypedia

TRPM1 antibodies


PROTEIN BROWSER

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ENST00000256552
 
ENST00000397795
 
ENST00000542188
 
ENST00000558445
 
ENST00000558768
 
ENST00000559177
 
ENST00000559179
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TRPM1-001 ENSP00000380897
ENST00000397795
Q7Z4N2
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Show » Show » 1603 182.2 No 8
TRPM1-002 ENSP00000453477
ENST00000559177
H0YM61
Show all »
Show » Show » 505 57.4 No 2
TRPM1-003 ENSP00000453851
ENST00000559179
Q7Z4N2
Show all »
Show » Show » 136 15.1 No 0
TRPM1-004 ENSP00000256552
ENST00000256552
Q7Z4N2
Show all »
Show » Show » 1625 184.8 No 7
TRPM1-007 ENSP00000453119
ENST00000558768
Show » Show » 1526 173.6 No 7
TRPM1-008 ENSP00000452946
ENST00000558445
H0YKU7
Show all »
Show » Show » 1390 158.4 No 8
TRPM1-201 ENSP00000437849
ENST00000542188
Q7Z4N2
Show all »
Show » Show » 1642 186.5 No 8