VAV3

GENERAL INFORMATION

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Gene name

VAV3

Gene description

Vav 3 guanine nucleotide exchange factor

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Tissue enhanced (skin)

Protein evidence

Evidence at protein level

Protein localization

Nuclear and cytoplasmic expression at variable levels in most tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 2 antibodies.
HPA028138 , CAB002012
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (skin)

Organ

Expression



GENE INFORMATION

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Gene name

VAV3

Synonyms

Description

Vav 3 guanine nucleotide exchange factor (HGNC Symbol)

Entrez gene summary

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p13.3

Chromosome location (bp)

107571160 - 107965144

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000134215 (version 78.38)

Entrez gene

10451

UniProt

Q9UKW4 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UKW4

Antibodypedia

VAV3 antibodies


PROTEIN BROWSER

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ENST00000370056
 
ENST00000415432
 
ENST00000490388
 
ENST00000527011
 
ENST00000529809
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

VAV3-001 ENSP00000359073
ENST00000370056
Q9UKW4
Show all »
Show » Show » 847 97.8 No 0
VAV3-005 ENSP00000394897
ENST00000415432
Q9UKW4
Show all »
Show » Show » 287 32.6 No 0
VAV3-006 ENSP00000433559
ENST00000490388
Show » Show » 616 71.4 No 0
VAV3-007 ENSP00000432540
ENST00000527011
Q9UKW4
Show all »
Show » Show » 875 100.8 No 0
VAV3-012 ENSP00000431544
ENST00000529809
Show » Show » 182 20.5 No 0