GRB7

GENERAL INFORMATION

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Gene name

GRB7

Gene description

Growth factor receptor-bound protein 7

Protein class

Cancer-related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in several cell types.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Data reliability

Uncertain based on 3 antibodies.
HPA057084 , CAB005226 , CAB073538
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

GRB7

Synonyms

Description

Growth factor receptor-bound protein 7 (HGNC Symbol)

Entrez gene summary

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Chromosome

17

Cytoband

q12

Chromosome location (bp)

39737927 - 39747291

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000141738 (version 78.38)

Entrez gene

2886

UniProt

Q14451 (UniProt - Evidence at protein level)

neXtProt

NX_Q14451

Antibodypedia

GRB7 antibodies


PROTEIN BROWSER

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ENST00000309156
 
ENST00000394204
 
ENST00000394209
 
ENST00000394211
 
ENST00000445327
 
ENST00000577695
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GRB7-001 ENSP00000310771
ENST00000309156
Q14451
Show all »
Show » Show » 532 59.7 No 0
GRB7-002 ENSP00000377761
ENST00000394211
Q14451
Show all »
Show » Show » 532 59.7 No 0
GRB7-003 ENSP00000377754
ENST00000394204
Q14451
Show all »
Show » Show » 447 49.4 No 0
GRB7-006 ENSP00000403459
ENST00000445327
Q14451
Show all »
Show » Show » 555 62.1 No 0
GRB7-009 ENSP00000377759
ENST00000394209
Q14451
Show all »
Show » Show » 532 59.7 No 0
GRB7-011 ENSP00000463416
ENST00000577695
J3QL76
Show all »
Show » 118 12.6 No 0