DEFB1

GENERAL INFORMATION

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Gene name

DEFB1

Gene description

Defensin, beta 1

Protein class

Predicted secreted proteins
Transporters

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (kidney, salivary gland)
GTEx:Group enriched (kidney, pancreas, salivary gland)

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY

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Data reliability

Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A


PROTEIN EXPRESSION OVERVIEW

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Pending normal tissue annotation.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (kidney, salivary gland)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (kidney, pancreas, salivary gland)

Organ

Expression



GENE INFORMATION

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Gene name

DEFB1 (HGNC Symbol)

Synonyms

BD1, DEFB-1, DEFB101, HBD-1, HBD1, MGC51822

Description

Defensin, beta 1 (HGNC Symbol)

Entrez gene summary

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

p23.1

Chromosome location (bp)

6870575 - 6878022

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164825 (version 78.38)

Entrez gene

1672

UniProt

P60022 (UniProt - Evidence at protein level)

neXtProt

NX_P60022

Antibodypedia

DEFB1 antibodies


PROTEIN BROWSER

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ENST00000297439
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DEFB1-001 ENSP00000297439
ENST00000297439
P60022
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