APC

GENERAL INFORMATION

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Gene name

APC

Gene description

Adenomatous polyposis coli

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic and membranous expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA013349 , CAB025994
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

APC (HGNC Symbol)

Synonyms

DP2, DP2.5, DP3, PPP1R46

Description

Adenomatous polyposis coli (HGNC Symbol)

Entrez gene summary

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q22.2

Chromosome location (bp)

112707498 - 112846239

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000134982 (version 78.38)

Entrez gene

324

UniProt

P25054 (UniProt - Evidence at protein level)

neXtProt

NX_P25054

Antibodypedia

APC antibodies


PROTEIN BROWSER

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ENST00000257430
 
ENST00000504915
 
ENST00000507379
 
ENST00000508376
 
ENST00000509732
 
ENST00000512211
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APC-001 ENSP00000257430
ENST00000257430
P25054
Show all »
Show » Show » 2843 311.6 No 0
APC-002 ENSP00000423224
ENST00000507379
B7Z2B6
Show all »
Show » Show » 1135 126.2 No 0
APC-004 ENSP00000427089
ENST00000508376
P25054
Show all »
Show » Show » 2843 311.6 No 0
APC-005 ENSP00000423828
ENST00000512211
E9PFT7
Show all »
Show » Show » 1305 145.8 No 0
APC-008 ENSP00000426541
ENST00000509732
D6RFL6
Show all »
Show » Show » 118 13 No 0
APC-011 ENSP00000473355
ENST00000504915
R4GMU6
Show all »
Show » Show » 272 29.7 No 0