DCLK2

GENERAL INFORMATION

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Gene name

DCLK2

Gene description

Doublecortin-like kinase 2

Protein class

Cytoskeleton related proteins
Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (cerebral cortex)
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in CNS

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Data reliability

Supportive based on 1 antibody.
HPA015770
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (cerebral cortex)

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

DCLK2 (HGNC Symbol)

Synonyms

DCAMKL2, DCDC3, DCDC3B, DCK2, MGC45428

Description

Doublecortin-like kinase 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]

Chromosome

4

Cytoband

Chromosome location (bp)

150078274 - 150257457

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170390 (version 78.38)

Entrez gene

166614

UniProt

Q8N568 (UniProt - Evidence at transcript level)

neXtProt

NX_Q8N568

Antibodypedia

DCLK2 antibodies


PROTEIN BROWSER

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ENST00000296550
 
ENST00000302176
 
ENST00000506325
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DCLK2-001 ENSP00000296550
ENST00000296550
Q8N568
Show all »
Show » Show » 766 83.6 No 0
DCLK2-003 ENSP00000303887
ENST00000302176
Q8N568
Show all »
Show » Show » 783 85.4 No 0
DCLK2-004 ENSP00000427235
ENST00000506325
Q8N568
Show all »
Show » Show » 765 83.5 No 0