ADAM19

GENERAL INFORMATION

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Gene name

ADAM19

Gene description

ADAM metallopeptidase domain 19

Protein class

Enzymes
Plasma proteins
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

A subset of cells in renal glomeruli displayed strong cytoplasmic and nuclear positivity. Hepatocytes, thyroid gland and Leydig cells showed moderate cytoplasmic staining. Neuronal cells in cerebral cortex exhibited moderate nucleolar staining. Remaining normal tissues were generally negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA055537
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

ADAM19 (HGNC Symbol)

Synonyms

MLTNB

Description

ADAM metallopeptidase domain 19 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013]

Chromosome

5

Cytoband

q33.3

Chromosome location (bp)

157395534 - 157575775

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000135074 (version 78.38)

Entrez gene

8728

UniProt

Q9H013 (UniProt - Evidence at protein level)

neXtProt

NX_Q9H013

Antibodypedia

ADAM19 antibodies


PROTEIN BROWSER

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ENST00000257527
 
ENST00000517374
 
ENST00000517905
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAM19-001 ENSP00000257527
ENST00000257527
Q9H013
Show all »
Show » Show » 918 100.8 Yes 1
ADAM19-003 ENSP00000428654
ENST00000517905
Q9H013
Show all »
Show » Show » 955 105 Yes 1
ADAM19-004 ENSP00000431027
ENST00000517374
Q8TBU7
Show all »
Show » Show » 489 52.7 No 1