CDK4

GENERAL INFORMATION

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Gene name

CDK4

Gene description

Cyclin-dependent kinase 4

Protein class

Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

10
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY

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Data reliability

Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A


PROTEIN EXPRESSION OVERVIEW

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Pending normal tissue annotation.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

CDK4 (HGNC Symbol)

Synonyms

PSK-J3

Description

Cyclin-dependent kinase 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

q14.1

Chromosome location (bp)

57747727 - 57756013

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000135446 (version 78.38)

Entrez gene

1019

UniProt

P11802 (UniProt - Evidence at protein level)

neXtProt

NX_P11802

Antibodypedia

CDK4 antibodies


PROTEIN BROWSER

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ENST00000257904
 
ENST00000312990
 
ENST00000546489
 
ENST00000547281
 
ENST00000547853
 
ENST00000549606
 
ENST00000551800
 
ENST00000552254
 
ENST00000552388
 
ENST00000552862
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDK4-001 ENSP00000257904
ENST00000257904
P11802
Show all »
Show » Show » 303 33.7 No 0
CDK4-004 ENSP00000447005
ENST00000549606
F8VZ13
Show all »
Show » Show » 40 4.6 No 0
CDK4-005 ENSP00000449391
ENST00000551800
F8VXD2
Show all »
Show » Show » 132 14.9 No 0
CDK4-006 ENSP00000448963
ENST00000552388
F8VYH9
Show all »
Show » Show » 170 18.7 No 0
CDK4-007 ENSP00000447779
ENST00000546489
F8VZ51
Show all »
Show » Show » 208 23.5 No 0
CDK4-009 ENSP00000447274
ENST00000547281
F8VZZ0
Show all »
Show » Show » 186 21 No 0
CDK4-010 ENSP00000449725
ENST00000547853
Show » 2 0.2 No 0
CDK4-011 ENSP00000449179
ENST00000552254
F8VWX7
Show all »
Show » Show » 203 22.4 No 0
CDK4-012 ENSP00000446763
ENST00000552862
F8W1L8
Show all »
Show » Show » 115 12.5 No 0
CDK4-201 ENSP00000316889
ENST00000312990
Q96BE9
Show all »
Show » Show » 111 12 No 0