MMP7

GENERAL INFORMATION

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Gene name

MMP7

Gene description

Matrix metallopeptidase 7 (matrilysin, uterine)

Protein class

Cancer-related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (gallbladder)
GTEx:Tissue enhanced (kidney, salivary gland)

Protein evidence

Evidence at protein level

Protein localization

Subsets of cells in endometrial glands, gall bladder, adrenal gland, squamous epithelia and urothelia showed moderate cytoplasmic positivity. Remaining normal tissues were negative or weakly stained.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB025869
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Endometrium



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (gallbladder)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (kidney, salivary gland)

Organ

Expression



GENE INFORMATION

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Gene name

MMP7 (HGNC Symbol)

Synonyms

MPSL1, PUMP-1

Description

Matrix metallopeptidase 7 (matrilysin, uterine) (HGNC Symbol)

Entrez gene summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q22.2

Chromosome location (bp)

102520508 - 102530753

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137673 (version 78.38)

Entrez gene

4316

UniProt

P09237 (UniProt - Evidence at protein level)

neXtProt

NX_P09237

Antibodypedia

MMP7 antibodies


PROTEIN BROWSER

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ENST00000260227
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MMP7-001 ENSP00000260227
ENST00000260227
P09237
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