CASP6

GENERAL INFORMATION

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Gene name

CASP6

Gene description

Caspase 6, apoptosis-related cysteine peptidase

Protein class

Cancer-related genes
Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in selected tissues, including urinary bladder and gastrointestinal tract.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data.

Data reliability

Supportive based on 3 antibodies.
HPA011337 , HPA024303 , CAB003775
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

CASP6 (HGNC Symbol)

Synonyms

MCH2

Description

Caspase 6, apoptosis-related cysteine peptidase (HGNC Symbol)

Entrez gene summary

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q25

Chromosome location (bp)

109688622 - 109703583

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000138794 (version 78.38)

Entrez gene

839

UniProt

P55212 (UniProt - Evidence at protein level)

neXtProt

NX_P55212

Antibodypedia

CASP6 antibodies


PROTEIN BROWSER

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ENST00000265164
 
ENST00000352981
 
ENST00000503684
 
ENST00000505486
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CASP6-001 ENSP00000265164
ENST00000265164
P55212
Show all »
Show » Show » 293 33.3 No 0
CASP6-002 ENSP00000285333
ENST00000352981
P55212
Show all »
Show » Show » 204 22.6 No 0
CASP6-003 ENSP00000424080
ENST00000505486
D6RBM3
Show all »
Show » Show » 80 9.4 No 0
CASP6-004 ENSP00000427669
ENST00000503684
D6RHU3
Show all »
Show » Show » 143 16.7 No 0