BEST4

GENERAL INFORMATION

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Gene name

BEST4

Gene description

Bestrophin 4

Protein class

Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (colon, duodenum, rectum, small intestine)
GTEx:Group enriched (colon, small intestine)

Protein evidence

Evidence at protein level

Protein localization

RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Pending external verification. Presumed off target binding observed and disregarded. RNA data suggests expression in selected tissues.

Data reliability

Uncertain based on 1 antibody.
HPA058564
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (colon, duodenum, rectum, small intestine)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (colon, small intestine)

Organ

Expression



GENE INFORMATION

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Gene name

BEST4 (HGNC Symbol)

Synonyms

VMD2L2

Description

Bestrophin 4 (HGNC Symbol)

Entrez gene summary

This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The bestrophin 4 gene is predominantly expressed in the colon. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p34.1

Chromosome location (bp)

44783585 - 44787705

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000142959 (version 78.38)

Entrez gene

266675

UniProt

Q8NFU0 (UniProt - Evidence at transcript level)

neXtProt

NX_Q8NFU0

Antibodypedia

BEST4 antibodies


PROTEIN BROWSER

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ENST00000372207
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BEST4-001 ENSP00000361281
ENST00000372207
Q8NFU0
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