ATP1B1

GENERAL INFORMATION

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Gene name

ATP1B1

Gene description

ATPase, Na+/K+ transporting, beta 1 polypeptide

Protein class

Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

Intracellular,Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression with a membranous pattern.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 1 antibody.
HPA012911
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

ATP1B1 (HGNC Symbol)

Synonyms

ATP1B

Description

ATPase, Na+/K+ transporting, beta 1 polypeptide (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010]

Chromosome

1

Cytoband

q24.2

Chromosome location (bp)

169105697 - 169132722

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000143153 (version 78.38)

Entrez gene

481

UniProt

P05026 (UniProt - Evidence at protein level)

neXtProt

NX_P05026

Antibodypedia

ATP1B1 antibodies


PROTEIN BROWSER

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ENST00000367815
 
ENST00000367816
 
ENST00000494797
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP1B1-001 ENSP00000356789
ENST00000367815
P05026
Show all »
Show » Show » 303 35.1 No 1
ATP1B1-002 ENSP00000356790
ENST00000367816
P05026
Show all »
Show » Show » 303 35.1 No 1
ATP1B1-003 ENSP00000477015
ENST00000494797
V9GYR2
Show all »
Show » Show » 130 15.1 No 0