SLC13A3

GENERAL INFORMATION

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Gene name

SLC13A3

Gene description

Solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3

Protein class

Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

10
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (kidney)
GTEx:Tissue enriched (kidney)

Protein evidence

Evidence at protein level

Protein localization

Distinct basolateral membrane expression in proximal renal tubules and membranous expression in cytotrophoblasts.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Data reliability

Supportive based on 2 antibodies.
HPA014353 , HPA014736
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (kidney)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (kidney)

Organ

Expression



GENE INFORMATION

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Gene name

SLC13A3 (HGNC Symbol)

Synonyms

NADC3, SDCT2

Description

Solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 (HGNC Symbol)

Entrez gene summary

Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

q13.12

Chromosome location (bp)

46557823 - 46684467

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000158296 (version 78.38)

Entrez gene

64849

UniProt

Q8WWT9 (UniProt - Evidence at protein level)

neXtProt

NX_Q8WWT9

Antibodypedia

SLC13A3 antibodies


PROTEIN BROWSER

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ENST00000279027
 
ENST00000290317
 
ENST00000372121
 
ENST00000413164
 
ENST00000417157
 
ENST00000420568
 
ENST00000450298
 
ENST00000468915
 
ENST00000472148
 
ENST00000495082
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC13A3-001 ENSP00000279027
ENST00000279027
Q8WWT9
Show all »
Show » Show » 602 66.8 Yes >9
SLC13A3-002 ENSP00000397955
ENST00000417157
C9J4A3
Show all »
Show » Show » 185 20.6 No 3
SLC13A3-003 ENSP00000395095
ENST00000420568
X6RDV4
Show all »
Show » Show » 301 33.7 No 5
SLC13A3-004 ENSP00000394217
ENST00000450298
Show » Show » 236 26.7 No 4
SLC13A3-006 ENSP00000417784
ENST00000468915
C9J7L4
Show all »
Show » Show » 409 45.9 No 7
SLC13A3-007 ENSP00000420177
ENST00000472148
Q8WWT9
Show all »
Show » Show » 520 57.8 No >9
SLC13A3-008 ENSP00000419621
ENST00000495082
Q8WWT9
Show all »
Show » Show » 555 61.8 No >9
SLC13A3-009 ENSP00000415852
ENST00000413164
Q8WWT9
Show all »
Show » Show » 552 61.1 Yes >9
SLC13A3-010 ENSP00000361193
ENST00000372121
Show » Show » 248 27.7 No 3
SLC13A3-201 ENSP00000290317
ENST00000290317
Q8WWT9
Show all »
Show » Show » 555 61.8 No >9