The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Renal tubuli and airway epithelium showed distinct positivity in luminal membranes. Moderate to strong cytoplasmic positivity was observed in hepatocytes, gall bladder, pancreatic islets, endocrine glands, placenta and glial cells. Remaining normal cells were in general weakly stained or negative.
Moderate membranous and cytoplasmic positivity was observed in cells in lung, salivary glands, breast, kidney, bone marrow and lymphoid tissues. Remaining tissues were in general weakly stained or negative.
Most normal tissues displayed moderate cytoplasmic and membranous positivity. The gastrointestinal tract showed distinct staining in the luminal membranes. Ovarian follicles, intestine, pneumocytes and a subset of lymphoid cells in the germinal center of lymph nodes showed strong positivity. Most cells in CNS were weakly stained or negative.
Most normal tissues displayed weak to moderate cell membranous staining. Strong membranous positivity was observed in lung tissue whereas lymphoid tissues exhibited strong cytoplasmic staining. Glandular cells of gastrointestinal tract, liver, squamous epithelia and myocytes were negative.
Normal tissues displayed weak to moderate cytoplasmic staining with additional membranous positivity in breast, renal tubules, fallopian tube, salivary gland and glandular cells of uterus. Hematopoietic cells, renal tubules, glandular cells of uterus and non-germinal center cells of lymphoid tissue were strongly stained. Bronchus, glial cells, placenta, prostate, rectum, seminal vesicle and skeletal muscle were negative.