OGT

GENERAL INFORMATION

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Gene name

OGT

Gene description

O-linked N-acetylglucosamine (GlcNAc) transferase

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic and nuclear expression in essentially all cells except in spleen, muscle, bile ducts, endothelial and stroma cells.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 4 antibodies.
HPA030751 , HPA030752 , HPA030754 , CAB034099
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

OGT (HGNC Symbol)

Synonyms

FLJ23071, HRNT1, MGC22921, O-GLCNAC

Description

O-linked N-acetylglucosamine (GlcNAc) transferase (HGNC Symbol)

Entrez gene summary

This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Chromosome

X

Cytoband

q13.1

Chromosome location (bp)

71533083 - 71575897

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000147162 (version 78.38)

Entrez gene

8473

UniProt

O15294 (UniProt - Evidence at protein level)

neXtProt

NX_O15294

Antibodypedia

OGT antibodies


PROTEIN BROWSER

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ENST00000373701
 
ENST00000373719
 
ENST00000444774
 
ENST00000455587
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

OGT-001 ENSP00000362824
ENST00000373719
O15294
Show all »
Show » Show » 1046 116.9 No 0
OGT-002 ENSP00000362805
ENST00000373701
O15294
Show all »
Show » Show » 1036 115.7 No 0
OGT-010 ENSP00000407659
ENST00000455587
Show » Show » 211 23.4 No 0
OGT-011 ENSP00000399729
ENST00000444774
C9JZL3
Show all »
Show » Show » 156 17.6 No 0