MAGEA4

GENERAL INFORMATION

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Gene name

MAGEA4

Gene description

Melanoma antigen family A, 4

Protein class

Cancer-related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

14
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein localization

Selective expression in seminiferous ducts of testis.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data. Pending retesting.

Data reliability

Supportive based on 2 antibodies.
HPA021942 , CAB040535
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (testis)

Organ

Expression



GENE INFORMATION

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Gene name

MAGEA4 (HGNC Symbol)

Synonyms

CT1.4, MAGE-41, MAGE-X2, MAGE4, MAGE4A, MAGE4B, MGC21336

Description

Melanoma antigen family A, 4 (HGNC Symbol)

Entrez gene summary

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

X

Cytoband

q28

Chromosome location (bp)

151912509 - 151925170

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000147381 (version 78.38)

Entrez gene

4103

UniProt

P43358 (UniProt - Evidence at protein level)

neXtProt

NX_P43358

Antibodypedia

MAGEA4 antibodies


PROTEIN BROWSER

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ENST00000276344
 
ENST00000360243
 
ENST00000370335
 
ENST00000370340
 
ENST00000393920
 
ENST00000393921
 
ENST00000416020
 
ENST00000425182
 
ENST00000430273
 
ENST00000431963
 
ENST00000431971
 
ENST00000441865
 
ENST00000448295
 
ENST00000457310
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAGEA4-001 ENSP00000391904
ENST00000448295
C9J9C2
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Show » 217 23.3 No 1
MAGEA4-002 ENSP00000390096
ENST00000431971
C9JIR1
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Show » 241 26 No 0
MAGEA4-003 ENSP00000394149
ENST00000430273
C9JIR1
Show all »
Show » 241 26 No 0
MAGEA4-004 ENSP00000394073
ENST00000416020
C9JK50
Show all »
Show » 230 24.7 No 0
MAGEA4-005 ENSP00000402624
ENST00000441865
C9JIR1
Show all »
Show » 241 26 No 0
MAGEA4-006 ENSP00000400900
ENST00000425182
C9J9C2
Show all »
Show » 217 23.3 No 1
MAGEA4-007 ENSP00000402186
ENST00000457310
C9JIR1
Show all »
Show » 241 26 No 0
MAGEA4-008 ENSP00000359365
ENST00000370340
P43358
Show all »
Show » Show » 317 34.9 No 0
MAGEA4-009 ENSP00000359360
ENST00000370335
P43358
Show all »
Show » Show » 317 34.9 No 0
MAGEA4-010 ENSP00000353379
ENST00000360243
P43358
Show all »
Show » Show » 317 34.9 No 0
MAGEA4-011 ENSP00000387777
ENST00000431963
C9JZJ5
Show all »
Show » 172 18.6 No 0
MAGEA4-201 ENSP00000276344
ENST00000276344
P43358
Show all »
Show » Show » 317 34.9 No 0
MAGEA4-202 ENSP00000377497
ENST00000393920
P43358
Show all »
Show » Show » 317 34.9 No 0
MAGEA4-203 ENSP00000377498
ENST00000393921
P43358
Show all »
Show » Show » 317 34.9 No 0