CHRNA6

GENERAL INFORMATION

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Gene name

CHRNA6

Gene description

Cholinergic receptor, nicotinic, alpha 6 (neuronal)

Protein class

Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Not detected
GTEx:Group enriched (cerebellum)

Protein evidence

Evidence at transcript level

ANTIBODY RELIABILITY

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Data reliability

Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A


PROTEIN EXPRESSION OVERVIEW

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Pending normal tissue annotation.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Not detected

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (cerebellum)

Organ

Expression



GENE INFORMATION

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Gene name

CHRNA6

Synonyms

Description

Cholinergic receptor, nicotinic, alpha 6 (neuronal) (HGNC Symbol)

Entrez gene summary

This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence. [provided by RefSeq, Dec 2010]

Chromosome

8

Cytoband

p11.21

Chromosome location (bp)

42752620 - 42796392

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000147434 (version 78.38)

Entrez gene

8973

UniProt

Q15825 (UniProt - Evidence at transcript level)

neXtProt

NX_Q15825

Antibodypedia

CHRNA6 antibodies


PROTEIN BROWSER

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ENST00000276410
 
ENST00000533810
 
ENST00000534622
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CHRNA6-001 ENSP00000276410
ENST00000276410
Q15825
Show all »
Show » Show » 494 56.9 Yes 4
CHRNA6-004 ENSP00000433871
ENST00000534622
Q15825
Show all »
Show » Show » 479 55 Yes 4
CHRNA6-005 ENSP00000434659
ENST00000533810
E9PP97
Show all »
Show » Show » 111 13.1 No 0