ABCG4

GENERAL INFORMATION

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Gene name

ABCG4

Gene description

ATP-binding cassette, sub-family G (WHITE), member 4

Protein class

Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

Intracellular,Membrane

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (cerebral cortex, testis)
GTEx:Tissue enhanced (cerebellum)

Protein evidence

Evidence at protein level

Protein localization

RNA data suggests expression in a selected group of tissues, most abundant in CNS. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Presumed off target binding observed and disregarded. Pending external verification.

Data reliability

Uncertain based on 1 antibody.
HPA040312
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (cerebral cortex, testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (cerebellum)

Organ

Expression



GENE INFORMATION

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Gene name

ABCG4 (HGNC Symbol)

Synonyms

WHITE2

Description

ATP-binding cassette, sub-family G (WHITE), member 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily and is expressed predominantly in liver tissue. The function has not yet been determined but may involve cholesterol transport. Alternate splice variants have been described but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q23.3

Chromosome location (bp)

119149012 - 119162653

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000172350 (version 78.38)

Entrez gene

64137

UniProt

Q9H172 (UniProt - Evidence at protein level)

neXtProt

NX_Q9H172

Antibodypedia

ABCG4 antibodies


PROTEIN BROWSER

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ENST00000524604
 
ENST00000615496
 
ENST00000619701
 
ENST00000622721
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCG4-001 ENSP00000481728
ENST00000619701
Q9H172
Show all »
Show » Show » 646 71.9 No 7
ABCG4-002 ENSP00000479253
ENST00000615496
Q9H172
Show all »
Show » Show » 646 71.9 No 7
ABCG4-003 ENSP00000484289
ENST00000622721
Q9H172
Show all »
Show » Show » 646 71.9 No 7
ABCG4-005 ENSP00000431915
ENST00000524604
E9PJ00
Show all »
Show » Show » 152 16.8 No 0