DLG5

GENERAL INFORMATION

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Gene name

DLG5

Gene description

Discs, large homolog 5 (Drosophila)

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

All neuronal tissues, including neurophil, showed strong nuclear and cytoplasmic positivity. Remaining normal cells were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA000555
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lateral ventricle

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

DLG5 (HGNC Symbol)

Synonyms

KIAA0583, P-dlg

Description

Discs, large homolog 5 (Drosophila) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

q22.3

Chromosome location (bp)

77790791 - 77926526

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000151208 (version 78.38)

Entrez gene

9231

UniProt

Q8TDM6 (UniProt - Evidence at protein level)

neXtProt

NX_Q8TDM6

Antibodypedia

DLG5 antibodies


PROTEIN BROWSER

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ENST00000372391
 
ENST00000424842
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DLG5-001 ENSP00000361467
ENST00000372391
Q8TDM6
Show all »
Show » Show » 1919 213.9 No 0
DLG5-005 ENSP00000394797
ENST00000424842
Show » Show » 880 96.7 No 0