MRPL23

GENERAL INFORMATION

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Gene name

MRPL23

Gene description

Mitochondrial ribosomal protein L23

Protein class

Mitochondrial proteins
Predicted intracellular proteins
Ribosomal proteins

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues displayed moderate to strong cytoplasmic and occasional nuclear positivity. Pneumocytes, bile ducts, renal glomeruli, skeletal myocytes and soft tissues were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA050406
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

MRPL23 (HGNC Symbol)

Synonyms

L23MRP, RPL23L

Description

Mitochondrial ribosomal protein L23 (HGNC Symbol)

Entrez gene summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. The gene is biallelically expressed, despite its location within a region of imprinted genes on chromosome 11. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

p15.5

Chromosome location (bp)

1947278 - 1984522

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000214026 (version 78.38)

Entrez gene

6150

UniProt

Q16540 (UniProt - Evidence at protein level)

neXtProt

NX_Q16540

Antibodypedia

MRPL23 antibodies


PROTEIN BROWSER

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ENST00000381514
 
ENST00000381519
 
ENST00000397294
 
ENST00000397297
 
ENST00000397298
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MRPL23-001 ENSP00000380466
ENST00000397298
Q16540
Show all »
Show » Show » 153 17.8 No 0
MRPL23-002 ENSP00000370925
ENST00000381514
A6NJD9
Show all »
Show » Show » 163 18.5 No 0
MRPL23-007 ENSP00000370930
ENST00000381519
Q16540
Show all »
Show » Show » 153 17.8 No 0
MRPL23-009 ENSP00000380465
ENST00000397297
A8MYK1
Show all »
Show » Show » 191 21.8 No 0
MRPL23-011 ENSP00000380462
ENST00000397294
A8MVT4
Show all »
Show » Show » 166 18.8 No 0