NCK1

GENERAL INFORMATION

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Gene name

NCK1

Gene description

NCK adaptor protein 1

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

9
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression, often with a granular pattern.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
CAB005063
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

NCK1 (HGNC Symbol)

Synonyms

NCK, NCKalpha

Description

NCK adaptor protein 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]

Chromosome

3

Cytoband

q22.3

Chromosome location (bp)

136862208 - 136949823

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000158092 (version 78.38)

Entrez gene

4690

UniProt

P16333 (UniProt - Evidence at protein level)

neXtProt

NX_P16333

Antibodypedia

NCK1 antibodies


PROTEIN BROWSER

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ENST00000288986
 
ENST00000467911
 
ENST00000469404
 
ENST00000476286
 
ENST00000481752
 
ENST00000485096
 
ENST00000488930
 
ENST00000491539
 
ENST00000496489
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NCK1-001 ENSP00000288986
ENST00000288986
P16333
Show all »
Show » Show » 377 42.9 No 0
NCK1-002 ENSP00000419631
ENST00000469404
P16333
Show all »
Show » Show » 313 35.5 No 0
NCK1-003 ENSP00000417273
ENST00000481752
P16333
Show all »
Show » Show » 377 42.9 No 0
NCK1-004 ENSP00000419302
ENST00000491539
C9JVV5
Show all »
Show » Show » 129 14.9 No 0
NCK1-005 ENSP00000419677
ENST00000485096
C9K098
Show all »
Show » Show » 115 13.2 No 0
NCK1-006 ENSP00000418513
ENST00000476286
C9J0K5
Show all »
Show » Show » 75 8.8 No 0
NCK1-009 ENSP00000417729
ENST00000488930
C9J869
Show all »
Show » Show » 162 18.4 No 0
NCK1-010 ENSP00000419544
ENST00000496489
Show » Show » 141 16.1 No 0
NCK1-011 ENSP00000418060
ENST00000467911
C9JAB9
Show all »
Show » Show » 174 20.1 No 0