GART

GENERAL INFORMATION

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Gene name

GART

Gene description

Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

Protein class

Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded. Antibody staining in cells/structures not annotated, view images.

Data reliability

Uncertain based on 2 antibodies.
HPA002119 , HPA005779
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Breast



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

GART (HGNC Symbol)

Synonyms

PGFT, PRGS

Description

Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

21

Cytoband

q22.11

Chromosome location (bp)

33503931 - 33543491

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000159131 (version 78.38)

Entrez gene

2618

UniProt

P22102 (UniProt - Evidence at protein level)

neXtProt

NX_P22102

Antibodypedia

GART antibodies


PROTEIN BROWSER

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ENST00000361093
 
ENST00000381815
 
ENST00000381831
 
ENST00000381839
 
ENST00000426819
 
ENST00000430874
 
ENST00000438059
 
ENST00000441403
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GART-001 ENSP00000371253
ENST00000381831
P22102
Show all »
Show » Show » 1010 107.8 No 0
GART-003 ENSP00000371236
ENST00000381815
P22102
Show all »
Show » Show » 1010 107.8 No 0
GART-004 ENSP00000354388
ENST00000361093
P22102
Show all »
Show » Show » 433 46 No 0
GART-006 ENSP00000371261
ENST00000381839
P22102
Show all »
Show » Show » 1010 107.8 No 0
GART-007 ENSP00000413040
ENST00000430874
C9JTV6
Show all »
Show » Show » 241 25.2 No 0
GART-008 ENSP00000413803
ENST00000438059
C9JKQ7
Show all »
Show » Show » 138 14.7 No 0
GART-009 ENSP00000398631
ENST00000426819
C9JBJ1
Show all »
Show » Show » 232 24.3 No 0
GART-010 ENSP00000407783
ENST00000441403
C9JZG2
Show all »
Show » Show » 136 14.5 No 0