IGF2BP1

GENERAL INFORMATION

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Gene name

IGF2BP1

Gene description

Insulin-like growth factor 2 mRNA binding protein 1

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (kidney, placenta, testis)
GTEx:Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression mainly in cells in seminiferous ducts of testis and follicle cells in ovary.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 2 antibodies.
HPA021367 , HPA062273
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Ovary



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (kidney, placenta, testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (testis)

Organ

Expression



GENE INFORMATION

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Gene name

IGF2BP1 (HGNC Symbol)

Synonyms

IMP-1

Description

Insulin-like growth factor 2 mRNA binding protein 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Chromosome

17

Cytoband

q21.32

Chromosome location (bp)

48997412 - 49055650

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000159217 (version 78.38)

Entrez gene

10642

UniProt

Q9NZI8 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NZI8

Antibodypedia

IGF2BP1 antibodies


PROTEIN BROWSER

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ENST00000290341
 
ENST00000431824
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IGF2BP1-001 ENSP00000290341
ENST00000290341
Q9NZI8
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Show » Show » 577 63.5 No 0
IGF2BP1-002 ENSP00000389135
ENST00000431824
Q9NZI8
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Show » Show » 438 48.6 No 0