VAV2

GENERAL INFORMATION

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Gene name

VAV2

Gene description

Vav 2 guanine nucleotide exchange factor

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Strong cytoplasmic positivity was observed in most glandular cells, especially in the gastrointestinal tract. Moderate staining was found in a fraction of cells in squamous epithelia and respiratory epithelia. Lymphoid tissues, cells of the CNS and muscle tissues were in general weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA003224
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

VAV2

Synonyms

Description

Vav 2 guanine nucleotide exchange factor (HGNC Symbol)

Entrez gene summary

VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Chromosome

9

Cytoband

q34.2

Chromosome location (bp)

133761894 - 133992604

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000160293 (version 78.38)

Entrez gene

7410

UniProt

P52735 (UniProt - Evidence at protein level)

neXtProt

NX_P52735

Antibodypedia

VAV2 antibodies


PROTEIN BROWSER

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ENST00000371850
 
ENST00000371851
 
ENST00000406606
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

VAV2-001 ENSP00000360916
ENST00000371850
P52735
Show all »
Show » Show » 878 101.3 No 0
VAV2-002 ENSP00000360917
ENST00000371851
P52735
Show all »
Show » Show » 868 100.1 No 0
VAV2-003 ENSP00000385362
ENST00000406606
P52735
Show all »
Show » Show » 839 97 No 0