SYVN1

GENERAL INFORMATION

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Gene name

SYVN1

Gene description

Synovial apoptosis inhibitor 1, synoviolin

Protein class

Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in most tissues. Most abundant in exocrine pancreas, placental trophoblasts, cells in the CNS, and a subset of leukocytes.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA005480 , HPA024300 , CAB037030
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

SYVN1 (HGNC Symbol)

Synonyms

DER3, HRD1

Description

Synovial apoptosis inhibitor 1, synoviolin (HGNC Symbol)

Entrez gene summary

This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms. [provided by RefSeq, May 2011]

Chromosome

11

Cytoband

q13.1

Chromosome location (bp)

65121780 - 65134533

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000162298 (version 78.38)

Entrez gene

84447

UniProt

Q86TM6 (UniProt - Evidence at protein level)

neXtProt

NX_Q86TM6

Antibodypedia

SYVN1 antibodies


PROTEIN BROWSER

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ENST00000294256
 
ENST00000307289
 
ENST00000377190
 
ENST00000526060
 
ENST00000528487
 
ENST00000531018
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SYVN1-001 ENSP00000366395
ENST00000377190
Q86TM6
Show all »
Show » Show » 617 67.7 Yes 5
SYVN1-002 ENSP00000294256
ENST00000294256
Q86TM6
Show all »
Show » Show » 616 67.6 Yes 5
SYVN1-004 ENSP00000436984
ENST00000526060
Q86TM6
Show all »
Show » Show » 616 67.6 Yes 5
SYVN1-005 ENSP00000431720
ENST00000528487
E9PK19
Show all »
Show » 237 27.6 Yes 4
SYVN1-007 ENSP00000431215
ENST00000531018
E9PMA1
Show all »
Show » 236 27.7 No 4
SYVN1-011 ENSP00000302035
ENST00000307289
Q86TM6
Show all »
Show » Show » 565 61.7 Yes 5