CAPN2

GENERAL INFORMATION

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Gene name

CAPN2

Gene description

Calpain 2, (m/II) large subunit

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Respiratory epithelium of the bronchus exhibited strong cytoplasmic staining. Urothelium, stomach, rectum, adrenal gland, renal distal tubules and glomeruli showed moderate cytoplasmic immunoreactivity. Remaining normal tissues were generally negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA024470
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

CAPN2 (HGNC Symbol)

Synonyms

CANPL2, CANPml, mCANP

Description

Calpain 2, (m/II) large subunit (HGNC Symbol)

Entrez gene summary

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Chromosome

1

Cytoband

q41

Chromosome location (bp)

223701593 - 223776018

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000162909 (version 78.38)

Entrez gene

824

UniProt

P17655 (UniProt - Evidence at protein level)

neXtProt

NX_P17655

Antibodypedia

CAPN2 antibodies


PROTEIN BROWSER

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ENST00000295006
 
ENST00000433674
 
ENST00000434648
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CAPN2-001 ENSP00000295006
ENST00000295006
P17655
Show all »
Show » Show » 700 80 No 0
CAPN2-009 ENSP00000399949
ENST00000434648
C9JWY7
Show all »
Show » Show » 131 14.4 No 0
CAPN2-201 ENSP00000413158
ENST00000433674
P17655
Show all »
Show » Show » 622 71.5 No 0