ACSL6

GENERAL INFORMATION

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Gene name

ACSL6

Gene description

Acyl-CoA synthetase long-chain family member 6

Protein class

Cancer-related genes
Disease related genes
Enzymes
Mitochondrial proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

16
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (bone marrow, cerebral cortex, testis)
GTEx:Group enriched (cerebellum, cerebral cortex, hippocampus, testis)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in most tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending external verification.

Data reliability

Uncertain based on 1 antibody.
HPA040470
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (bone marrow, cerebral cortex, testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (cerebellum, cerebral cortex, hippocampus, testis)

Organ

Expression



GENE INFORMATION

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Gene name

ACSL6 (HGNC Symbol)

Synonyms

ACS2, FACL6, KIAA0837, LACS2, LACS5

Description

Acyl-CoA synthetase long-chain family member 6 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011]

Chromosome

5

Cytoband

q31.1

Chromosome location (bp)

131806990 - 132012243

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164398 (version 78.38)

Entrez gene

23305

UniProt

Q9UKU0 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9UKU0

Antibodypedia

ACSL6 antibodies


PROTEIN BROWSER

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ENST00000296869
 
ENST00000357096
 
ENST00000379240
 
ENST00000379244
 
ENST00000379246
 
ENST00000379255
 
ENST00000379264
 
ENST00000414078
 
ENST00000416557
 
ENST00000419502
 
ENST00000430403
 
ENST00000431707
 
ENST00000434099
 
ENST00000441995
 
ENST00000543479
 
ENST00000616644
 
 » 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACSL6-001 ENSP00000368566
ENST00000379264
Q9UKU0
Show all »
Show » Show » 722 80.6 No 3
ACSL6-002 ENSP00000368548
ENST00000379246
Q9UKU0
Show all »
Show » Show » 708 79 No 2
ACSL6-003 ENSP00000368557
ENST00000379255
Q9UKU0
Show all »
Show » Show » 622 69.2 No 0
ACSL6-004 ENSP00000368542
ENST00000379240
Q9UKU0
Show all »
Show » Show » 697 77.8 No 2
ACSL6-005 ENSP00000397507
ENST00000434099
C9J8C7
Show all »
Show » Show » 365 40.8 No 0
ACSL6-008 ENSP00000368546
ENST00000379244
Q9UKU0
Show all »
Show » Show » 697 77.7 No 2
ACSL6-009 ENSP00000296869
ENST00000296869
Q9UKU0
Show all »
Show » Show » 722 80.5 No 3
ACSL6-011 ENSP00000398423
ENST00000430403
C9J3Z0
Show all »
Show » Show » 213 23.9 No 1
ACSL6-012 ENSP00000388424
ENST00000419502
C9JK59
Show all »
Show » 152 17 No 1
ACSL6-016 ENSP00000394810
ENST00000414078
C9JPA5
Show all »
Show » 135 15.2 No 1
ACSL6-017 ENSP00000389189
ENST00000441995
C9JT10
Show all »
Show » 100 11.3 No 0
ACSL6-018 ENSP00000413329
ENST00000431707
E7ERD7
Show all »
Show » Show » 677 75.2 No 0
ACSL6-019 ENSP00000398381
ENST00000416557
C9J4I1
Show all »
Show » 144 16.1 No 1
ACSL6-201 ENSP00000349608
ENST00000357096
Q9UKU0
Show all »
Show » Show » 622 69.2 No 0
ACSL6-202 ENSP00000442124
ENST00000543479
Q9UKU0
Show all »
Show » Show » 712 79.1 No 2
ACSL6-203 ENSP00000481155
ENST00000616644
Show » 333 36.4 No 0