PGAM2

GENERAL INFORMATION

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Gene name

PGAM2

Gene description

Phosphoglycerate mutase 2 (muscle)

Protein class

Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (heart muscle, skeletal muscle)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression most abundant in heart and skeletal muscle.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.

Data reliability

Uncertain based on 2 antibodies.
HPA049237 , HPA060173
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (heart muscle, skeletal muscle)

Organ

Expression



GENE INFORMATION

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Gene name

PGAM2 (HGNC Symbol)

Synonyms

PGAM-M

Description

Phosphoglycerate mutase 2 (muscle) (HGNC Symbol)

Entrez gene summary

Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X. [provided by RefSeq, Sep 2009]

Chromosome

7

Cytoband

p13

Chromosome location (bp)

44062727 - 44065587

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164708 (version 78.38)

Entrez gene

5224

UniProt

P15259 (UniProt - Evidence at protein level)

neXtProt

NX_P15259

Antibodypedia

PGAM2 antibodies


PROTEIN BROWSER

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ENST00000297283
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PGAM2-001 ENSP00000297283
ENST00000297283
P15259
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