INTS1

GENERAL INFORMATION

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Gene name

INTS1

Gene description

Integrator complex subunit 1

Protein class

Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Moderate cytoplasmic positivity was observed in most normal tissues. Exocrine pancreas, thyroid gland and placenta showed strong cytoplasmic staining.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA021658
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Thyroid gland

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

INTS1 (HGNC Symbol)

Synonyms

DKFZp586J0619, INT1, KIAA1440, NET28

Description

Integrator complex subunit 1 (HGNC Symbol)

Entrez gene summary

INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

Chromosome

7

Cytoband

p22.3

Chromosome location (bp)

1470277 - 1504367

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164880 (version 78.38)

Entrez gene

26173

UniProt

Q8N201 (UniProt - Evidence at protein level)

neXtProt

NX_Q8N201

Antibodypedia

INTS1 antibodies


PROTEIN BROWSER

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ENST00000404767
 
ENST00000483196
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

INTS1-001 ENSP00000385722
ENST00000404767
Q8N201
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Show » Show » 2190 244.3 No 2
INTS1-008 ENSP00000419206
ENST00000483196
H7C582
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Show » 128 14 No 0