FUT3

GENERAL INFORMATION

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Gene name

FUT3

Gene description

Fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)

Protein class

Blood group antigen proteins
Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (colon, esophagus)
GTEx:Group enriched (cervix, uterine, colon, esophagus, salivary gland, small intestine, vagina)

Protein evidence

Evidence at protein level

Protein localization

Granular cytoplasmic expression in gastrointestinal tract.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Data reliability

Supportive based on 1 antibody.
HPA046966
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (colon, esophagus)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (cervix, uterine, colon, esophagus, salivary gland, small intestine, vagina)

Organ

Expression



GENE INFORMATION

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Gene name

FUT3 (HGNC Symbol)

Synonyms

CD174, LE

Description

Fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) (HGNC Symbol)

Entrez gene summary

The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

p13.3

Chromosome location (bp)

5842888 - 5851474

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000171124 (version 78.38)

Entrez gene

2525

UniProt

P21217 (UniProt - Evidence at transcript level)

neXtProt

NX_P21217

Antibodypedia

FUT3 antibodies


PROTEIN BROWSER

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ENST00000303225
 
ENST00000458379
 
ENST00000585715
 
ENST00000587048
 
ENST00000587183
 
ENST00000589620
 
ENST00000589714
 
ENST00000589918
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FUT3-001 ENSP00000468123
ENST00000589918
P21217
Show all »
Show » Show » 361 42.1 No 0
FUT3-002 ENSP00000305603
ENST00000303225
P21217
Show all »
Show » Show » 361 42.1 No 0
FUT3-003 ENSP00000465804
ENST00000589620
P21217
Show all »
Show » Show » 361 42.1 No 0
FUT3-004 ENSP00000416443
ENST00000458379
P21217
Show all »
Show » Show » 361 42.1 No 0
FUT3-008 ENSP00000467081
ENST00000589714
K7ENT3
Show all »
Show » Show » 107 11.9 No 1
FUT3-009 ENSP00000468515
ENST00000587048
K7ES24
Show all »
Show » Show » 100 11.2 No 1
FUT3-011 ENSP00000468795
ENST00000587183
Show » 5 0.5 No 0
FUT3-012 ENSP00000467633
ENST00000585715
K7EQ20
Show all »
Show » Show » 44 5 No 1