SOCS5

GENERAL INFORMATION

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Gene name

SOCS5

Gene description

Suppressor of cytokine signaling 5

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA020884 , CAB025510
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

SOCS5 (HGNC Symbol)

Synonyms

CIS6, Cish5, CISH6, KIAA0671, SOCS-5

Description

Suppressor of cytokine signaling 5 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

p21

Chromosome location (bp)

46698952 - 46763129

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000171150 (version 78.38)

Entrez gene

9655

UniProt

O75159 (UniProt - Evidence at protein level)

neXtProt

NX_O75159

Antibodypedia

SOCS5 antibodies


PROTEIN BROWSER

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ENST00000306503
 
ENST00000394861
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SOCS5-001 ENSP00000305133
ENST00000306503
O75159
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Show » Show » 536 61.2 No 0
SOCS5-002 ENSP00000378330
ENST00000394861
O75159
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Show » Show » 536 61.2 No 0