LEMD3

GENERAL INFORMATION

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Gene name

LEMD3

Gene description

LEM domain containing 3

Protein class

Disease related genes
Plasma proteins
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Normal cells showed moderate nuclear/nuclear membrane positivity in combination with cytoplasmic staining. Strong staining was observed in the gastric mucosa and seminiferus duct cells. Spleen, tonsil, liver, thyroid, prostate and myocytes were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA025078
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

LEMD3 (HGNC Symbol)

Synonyms

MAN1

Description

LEM domain containing 3 (HGNC Symbol)

Entrez gene summary

This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.[provided by RefSeq, Nov 2009]

Chromosome

12

Cytoband

q14.3

Chromosome location (bp)

65169571 - 65248327

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000174106 (version 78.38)

Entrez gene

23592

UniProt

Q9Y2U8 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y2U8

Antibodypedia

LEMD3 antibodies


PROTEIN BROWSER

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ENST00000308330
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LEMD3-001 ENSP00000308369
ENST00000308330
Q9Y2U8
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