KCNA2

GENERAL INFORMATION

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Gene name

KCNA2

Gene description

Potassium voltage-gated channel, shaker-related subfamily, member 2

Protein class

FDA approved drug targets
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (cerebral cortex, thyroid gland)
GTEx:Group enriched (cerebellum, cerebral cortex, hippocampus)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in neuronal cells and processes. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Presumed off target binding observed and disregarded. Pending external verification.

Data reliability

Uncertain based on 1 antibody.
CAB001976
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (cerebral cortex, thyroid gland)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (cerebellum, cerebral cortex, hippocampus)

Organ

Expression



GENE INFORMATION

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Gene name

KCNA2 (HGNC Symbol)

Synonyms

HK4, Kv1.2

Description

Potassium voltage-gated channel, shaker-related subfamily, member 2 (HGNC Symbol)

Entrez gene summary

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p13.3

Chromosome location (bp)

110593580 - 110631474

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000177301 (version 78.38)

Entrez gene

3737

UniProt

P16389 (UniProt - Evidence at protein level)

neXtProt

NX_P16389

Antibodypedia

KCNA2 antibodies


PROTEIN BROWSER

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ENST00000316361
 
ENST00000369770
 
ENST00000485317
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KCNA2-001 ENSP00000358785
ENST00000369770
P16389
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Show » Show » 356 41 No 3
KCNA2-002 ENSP00000433109
ENST00000485317
P16389
Show all »
Show » Show » 499 56.7 No 6
KCNA2-003 ENSP00000314520
ENST00000316361
P16389
Show all »
Show » Show » 499 56.7 No 6