SH2B1

GENERAL INFORMATION

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Gene name

SH2B1

Gene description

SH2B adaptor protein 1

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

14
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY

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Data reliability

Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A


PROTEIN EXPRESSION OVERVIEW

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Pending normal tissue annotation.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

SH2B1 (HGNC Symbol)

Synonyms

FLJ30542, SH2B

Description

SH2B adaptor protein 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

Chromosome

16

Cytoband

p11.2

Chromosome location (bp)

28846600 - 28874212

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000178188 (version 78.38)

Entrez gene

25970

UniProt

Q9NRF2 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NRF2

Antibodypedia

SH2B1 antibodies


PROTEIN BROWSER

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ENST00000322610
 
ENST00000337120
 
ENST00000359285
 
ENST00000395532
 
ENST00000538342
 
ENST00000545570
 
ENST00000561629
 
ENST00000563591
 
ENST00000566176
 
ENST00000566209
 
ENST00000567536
 
ENST00000568868
 
ENST00000569651
 
ENST00000618521
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SH2B1-001 ENSP00000321221
ENST00000322610
Q9NRF2
Show all »
Show » Show » 756 79.4 No 0
SH2B1-002 ENSP00000337163
ENST00000337120
Q9NRF2
Show all »
Show » Show » 671 70.8 No 0
SH2B1-003 ENSP00000352232
ENST00000359285
Q9NRF2
Show all »
Show » Show » 683 72.2 No 0
SH2B1-004 ENSP00000440354
ENST00000545570
F5GXU7
Show all »
Show » 373 40.3 No 0
SH2B1-005 ENSP00000438784
ENST00000538342
B4DLN5
Show all »
Show » 335 36.1 No 0
SH2B1-006 ENSP00000378903
ENST00000395532
Q9NRF2
Show all »
Show » Show » 671 70.8 No 0
SH2B1-007 ENSP00000457214
ENST00000566209
H3BTK4
Show all »
Show » Show » 57 6.2 No 0
SH2B1-008 ENSP00000458097
ENST00000563591
H3BVF6
Show all »
Show » Show » 63 6.7 No 0
SH2B1-009 ENSP00000455236
ENST00000567536
Show » 18 2 No 0
SH2B1-010 ENSP00000455534
ENST00000566176
H3BPZ4
Show all »
Show » 182 19.2 No 0
SH2B1-011 ENSP00000454601
ENST00000561629
H3BMY3
Show all »
Show » 122 13.1 No 0
SH2B1-014 ENSP00000457315
ENST00000568868
Show » 114 12.7 No 0
SH2B1-015 ENSP00000457724
ENST00000569651
Show » 200 23.1 No 0
SH2B1-201 ENSP00000481709
ENST00000618521
Q9NRF2
Show all »
Show » Show » 756 79.4 No 0