UCN3

GENERAL INFORMATION

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Gene name

UCN3

Gene description

Urocortin 3

Protein class

Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (duodenum, small intestine)
GTEx:Tissue enhanced (colon, pancreas, small intestine)

Protein evidence

Evidence at protein level

Protein localization

Most of the normal tissues displayed strong cytoplasmic positivity with a granular pattern. Glomeruli, bile ducts and glial cells were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA038281
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (duodenum, small intestine)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (colon, pancreas, small intestine)

Organ

Expression



GENE INFORMATION

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Gene name

UCN3 (HGNC Symbol)

Synonyms

SPC, UCNIII

Description

Urocortin 3 (HGNC Symbol)

Entrez gene summary

This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

p15.1

Chromosome location (bp)

5365009 - 5374692

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000178473 (version 78.38)

Entrez gene

114131

UniProt

Q969E3 (UniProt - Evidence at protein level)

neXtProt

NX_Q969E3

Antibodypedia

UCN3 antibodies


PROTEIN BROWSER

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ENST00000380433
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UCN3-001 ENSP00000369798
ENST00000380433
Q969E3
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