C1S

GENERAL INFORMATION

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Gene name

C1S

Gene description

Complement component 1, s subcomponent

Protein class

Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

9
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Distinct positivity in plasma.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA018852 , CAB016722
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Rectum

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

C1S

Synonyms

Description

Complement component 1, s subcomponent (HGNC Symbol)

Entrez gene summary

This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. [provided by RefSeq, Mar 2009]

Chromosome

12

Cytoband

p13.31

Chromosome location (bp)

6988259 - 7071032

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000182326 (version 78.38)

Entrez gene

716

UniProt

P09871 (UniProt - Evidence at protein level)

neXtProt

NX_P09871

Antibodypedia

C1S antibodies


PROTEIN BROWSER

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ENST00000328916
 
ENST00000360817
 
ENST00000402681
 
ENST00000403949
 
ENST00000406697
 
ENST00000413211
 
ENST00000423384
 
ENST00000542978
 
ENST00000617865
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

C1S-001 ENSP00000385035
ENST00000406697
P09871
Show all »
Show » Show » 688 76.7 Yes 0
C1S-003 ENSP00000328173
ENST00000328916
P09871
Show all »
Show » Show » 688 76.7 Yes 0
C1S-004 ENSP00000354057
ENST00000360817
P09871
Show all »
Show » Show » 688 76.7 Yes 0
C1S-005 ENSP00000399892
ENST00000423384
C9JY52
Show all »
Show » 101 11.5 Yes 0
C1S-006 ENSP00000406643
ENST00000413211
C9IZP8
Show all »
Show » 103 11.8 Yes 0
C1S-007 ENSP00000384464
ENST00000403949
B5MCV4
Show all »
Show » Show » 168 19.3 Yes 0
C1S-017 ENSP00000384171
ENST00000402681
F8WCZ6
Show all »
Show » Show » 521 57.5 No 0
C1S-019 ENSP00000442298
ENST00000542978
F5H7T4
Show all »
Show » 157 17.4 No 0
C1S-201 ENSP00000484657
ENST00000617865
Show » Show » 682 75.9 No 0