The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Most normal tissues displayed weak to moderate cytoplasmic positivity. Basal layer of skin, prostate and salivary gland displayed distinct cytoplasmic positivity. Additional distinct membranous staining was observed in epididymis, gall bladder and placenta.
Most normal tissues showed weak to moderate cytoplasmic positivity. Heart and skeletal muscle displayed strong immunoreactivity. Soft tissues, lymphoid tissues and cells in CNS were generally negative.
Moderate to strong cytoplasmic positivity with a granular pattern observed in small intestine, hepatocytes, urothelium, placental trophoblastic cells and subsets of cells in lymphoid tissues. Renal tubules showed moderate and cytoplasmic positivity. Remaining normal tissues were weakly stained or negative.