FLNA

GENERAL INFORMATION

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Gene name

FLNA

Gene description

Filamin A, alpha

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Selective cytoplasmic expression in smooth muscle, myoepithelia, squamous epithelia and subsets of lymphoid cells.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA001115 , HPA002925 , CAB000356
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

FLNA (HGNC Symbol)

Synonyms

ABP-280, FLN, FLN1, OPD1, OPD2

Description

Filamin A, alpha (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]

Chromosome

X

Cytoband

q28

Chromosome location (bp)

154348524 - 154374638

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000196924 (version 78.38)

Entrez gene

2316

UniProt

P21333 (UniProt - Evidence at protein level)

neXtProt

NX_P21333

Antibodypedia

FLNA antibodies


PROTEIN BROWSER

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ENST00000344736
 
ENST00000360319
 
ENST00000369850
 
ENST00000369856
 
ENST00000422373
 
ENST00000438732
 
ENST00000444578
 
ENST00000610817
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FLNA-001 ENSP00000353467
ENST00000360319
P21333
Show all »
Show » Show » 2639 280 No 0
FLNA-002 ENSP00000358866
ENST00000369850
P21333
Show all »
Show » Show » 2647 280.7 No 0
FLNA-010 ENSP00000358863
ENST00000344736
Q5HY54
Show all »
Show » Show » 2607 276.5 No 0
FLNA-015 ENSP00000398215
ENST00000438732
Show » Show » 232 25 No 0
FLNA-016 ENSP00000397824
ENST00000444578
H0Y5C6
Show all »
Show » Show » 281 29.9 No 0
FLNA-022 ENSP00000358872
ENST00000369856
Q60FE5
Show all »
Show » Show » 2620 278.2 No 0
FLNA-201 ENSP00000416926
ENST00000422373
P21333
Show all »
Show » Show » 2639 280 No 0
FLNA-202 ENSP00000480593
ENST00000610817
Q86TQ3
Show all »
Show » Show » 2315 245.8 No 0