SERPINA1

TISSUE ATLAS

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Gene description

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1

RNA tissue category

Tissue enriched (liver).

Protein class

Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Protein evidence

Evidence at protein level

Protein expression

Distinct positivity in plasma and expression in extracellular matrix in a majority of tissues.

Data reliability description

Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Data reliability

Supportive based on 5 antibodies.
Liver
Colon
Kidney
Testis
Lymph node
Cerebral cortex
Lung
RNA Protein

Expression (FPKM)

Organ system

Localization (score)

11200
5600
0

h
m
l
n

Liver and pancreas
Liver
Gallbladder N/A
Pancreas
Digestive tract (GI-tract)
N/A Oral mucosa
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Appendix
Colon N/A
Rectum
Urinary tract (Kidney and bladder)
Kidney
Urinary bladder
Male reproductive system (Male tissues)
Testis
N/A Epididymis
Prostate
N/A Seminal vesicle
Breast and female reproductive system
N/A Breast
N/A Vagina
N/A Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Skin and soft tissues
Skin
Adipose tissue
Skeletal muscle
Smooth muscle
N/A Soft tissue
Blood and immune system (Hematopoietic)
Bone marrow
Lymph node
Tonsil
Spleen
Central nervous system (Brain)
Cerebral cortex
N/A Hippocampus
N/A Lateral ventricle
N/A Cerebellum
Endocrine glands
Thyroid gland
N/A Parathyroid gland N/A
Adrenal gland
Respiratory system (Lung)
N/A Nasopharynx N/A
N/A Bronchus
Lung
Cardiovascular system
Heart muscle

Antibodies in assay

HPA000927 , HPA001292 , CAB013211 , CAB016648 , CAB073396